Public demo
Aggregate findings come from the real MIMIC-IV cohort run. Patient-level fields are redacted per the PhysioNet DUA. Inference was performed locally during the original run. Candidate table is capped at 200 rows
*
for this public demo.
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PARADIGM-HF
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Methodology
PARADIGM-HF
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NCT01035255 · 18 criteria · 2008 - 2010, 2011 - 2013
Hospital patients
364,627
Qualified by structured
15,602
Qualified by LLM
5,785
Enrolled
0
Disqualified by structured
349,025
Awaiting LLM
460
Disqualified by LLM
9,357
Criteria
Inclusion
Incl 1
Informed consent
screening visit
Incl 2a
Heart failure diagnosis (ICD I50 / 428)
structured
Incl 2b
Adult ≥ 18
structured
Incl 3a
NYHA functional class II–IV
llm
Incl 3b
LVEF ≤ 35%
llm
Incl 3c
NT-proBNP ≥ 400 pg/mL
llm
Incl 4
ACEi/ARB therapy ≥ 4 weeks, tolerated
llm
Incl 5
β-blocker therapy ≥ 4 weeks, tolerated
llm
Exclusion
Excl 1
Other investigational drugs within 30 days / 5 half-lives
screening visit
Excl 2
ACEi or ARB hypersensitivity
screening visit
Excl 3
Previous intolerance at target dose
screening visit
Excl 4a
Documented angioedema (ICD T78.3 / 995.1)
structured
Excl 4b
History of angioedema in the chart
llm
Excl 5
Concurrent ACEi + ARB
screening visit
Excl 6
Currently acute decompensated heart failure
screening visit
Excl 7
Symptomatic hypotension and/or SBP < 100 mmHg
screening visit
Excl 8
eGFR < 30 mL/min/1.73 m²
screening visit
Excl 9
Serum K+ > 5.2 mmol/L
screening visit
460 pre-note candidates ready for review
Run the local Gemma 4 screener over their chart notes.
Each note checked against 6 LLM criteria:
Incl 3a
Incl 3b
Incl 3c
Incl 4
Incl 5
Excl 4b
Local
Cloud
Patients:
Run note review
Show:
all
disqualified
pre-note
note candidate
enrolled
No candidates in the selected buckets.